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-synuclein, which is a principal component of Lewy bodies, in PARK 1 in 1997 and parkin in PARK two in 1998, which is an E3 ubiquitin ligase and will cause endoplasmic reticulum (ER) anxiety, recommend that dysfunction in the intracellular proteinase programs, including ubiquitin-proteasome method or lysosomal system, which eliminates needless harm
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